The Spiders, the hypnagogic online comic, has just put out the new part 3.5 (mirror). If you haven't read Spiders before then start at the beginning and get at least through part 2; that's where it gets interesting.
The story is a bit tough to follow at times, but the artwork and presentation are fantastic. My only frustration is that they use the Web medium so well I can't imagine these ever being printed.
Also not to miss by the same artist: Apocamon, the book of Revelation reinterpreted as manga.
As seen on MetaFilter, jwz