I hate InstallShield. It's big: last I checked it added a meg to the install package. That may be OK for a CD-ROM but it's unacceptable online. It's slow: it literally takes minutes to install and uninstall a 100 meg program. How hard is it to copy and delete files?! And it's funky: do you really want to use an installer technology that has a freakin training program? WISE isn't much better.
Installers should be simple. SuperPimp is good. Windows MSI Installer is OK too, but it requires the user already have the 1.7 meg environment installed. And Install Maker has gotten some traction by being simple and free.