We spend all day typing on keyboards. Most of those keyboards are awful; cheap switches, bad pitch, etc. But the layout is the worst problem. Either you have a giant 101 key keyboard that's too wide with a useless numeric keypad moving your mouse further to the right, or you have a small keyboard which has tiny arrow keys and loses the useful home, end, page up, and page down. these Tenkeyless keyboards with mechanical switches and liked it, although I'm back to a full size Apple keyboard with a mouse platform that fits over the vestigial numeric keypad.
Now if only we could do something about CapsLock.